Twin Research and Human Genetics

This study aims to qualitatively explore how fathers raising twins acquire their paternal roles and how their perceptions and attitudes change throughout the parenting process. The study was conducted through online semi-structured interviews with 10 fathers of twins, based on an interview guide. A qualitative inductive method was employed to analyze and structure fathers perceptions of childcare. An exploratory net was created from 388 labels, following which categories were derived through multi-stage pick-up, and groups were formed and illustrated. The resulting structure illustrated a dynamic process in which fathers, who were unable to fully comprehend what it meant to become a father of twins during pregnancy, confronted the unexpected realities of twin parenting after birth. This led to not only psychological and emotional challenges, but also gradual adaptations and transformations. The findings underscore the need for early interventions to support fathers and contribute to the development of comprehensive support systems that consider the complexities of parenting twins. In the future, developing phased support programs for fathers-- beginning in the prenatal period--and promoting broader social understanding involving families, communities, and workplaces will be essential in fostering environments that enable sustainable work-life balance for fathers.

Having a family member with mental disorder will affect their healthy family member life. This study to examine the factors impacted on adolescent well-being who have family member with mental disorder. This study was a literature review in two databases SCOPUS and Science which conducted by four steps: (1) identification of literature; (2) screening questions; (3) eligibility using inclusion criteria; and (4) assessment of the quality of the studies. This study found 17 article which then reviewed and analyzed. The study result found seven theme that impacted on well-being included the caregiving responsibilities; the caregiving perception; the caregiving supports; Coping; Caregiving burden; Caregiving positive effects; Psychological impact; Adaptation enhancing. This study the results show the need to explore the seven themes in relation to the conditions of well-being on adolescent who have family member with mental disorder.

Wellbeing is commonly defined as the combination of feeling good and functioning well and typically conceptualized as two related but distinct components. Hedonic wellbeing emphasizes pleasure, happiness, and life satisfaction, while eudaimonic wellbeing focuses on meaning, personal growth, flourishing, and the realization of ones potential. The Mental Health Continuum-Short Form was developed as a comprehensive measure of wellbeing and includes three subscales assessing emotional, social, and psychological wellbeing. Although the Mental Health Continuum total score is often interpreted as an indicator of overall wellbeing, the underlying genetic structure of its three subscales and its genetic overlap with other commonly used wellbeing measures remains unclear. Using data from 5,212 individuals from the Netherlands Twin Register (72% female, mean age 36.4), we fitted multivariate twin models to examine the genetic architecture of the Mental Health Continuum and its associations with other wellbeing measures (quality of life, life satisfaction, subjective happiness, and flourishing). Results indicate that, at the genetic level, the Mental Health Continuum is best explained by its three distinct subscales rather than by a latent factor. When considering the Mental Health Continuum together with the other wellbeing measures, we found moderate to high genetic correlations (r = 0.52 - 0.83), indicating substantial overlap in the genetics underlying the wellbeing constructs. However, we did not find evidence for a single common genetic factor underlying all constructs. These findings highlight the multidimensional structure of wellbeing, but the moderate to high genetic correlations across measures suggest that it is important to align the level of measurement (phenotypic vs genetic) with the research question.

Childhood weight development, especially overweight and obesity, has been associated with mental health, but their dynamic, causal relationships, and whether these differ by sex, remain unclear. We applied causal discovery to data from the Danish National Birth Cohort (n=67,593) spanning six periods from pregnancy to late adolescence and considering 67 variables related to child and parental weight, mental health, lifestyle, and socio-economic factors. We found no statistically significant difference between the causal graphs for boys and girls (P=0.079). The data-driven models found causal influence of childhood weight on subsequent weight status. Mental health pathways were exclusively within or across adjacent periods and centered on early adolescent stress. We examined the interplay between a subset of mental health variables, containing information on externalizing and internalizing problems, and weight, and found no direct causal pathway between the two processes. These findings suggest that observed links between weight and these mental health measures may be attributable to confounding. Our findings demonstrate the value of data-driven causal discovery in large cohort studies and how to test for differences in causal mechanisms across subgroups. Results are available in an interactive application, enabling future research to further explore the interplay between weight and mental health.

IntroductionEducational attainment (EA) is negatively associated with body mass index (BMI) but less is known about the association between EA and adult BMI change. We analyzed the role of genetic and environmental factors in the association between EA and BMI trajectory components over adulthood. Data and methodsPooled data from 59,490 twins aged 31-99 years (49% women) across 11 cohorts with EA and repeated measures of BMI were used. BMI trajectory components (baseline BMI and BMI change per decade) were estimated using linear mixed-effects (LME) and delta slope methods. EA was derived by regressing years of education on birth year and cohort. Associations between EA and BMI trajectories were evaluated with LME models in both cohort-specific and pooled data. Genetic and environmental contributions were evaluated using structural equation modeling. ResultsEA was more strongly negatively associated with baseline BMI and BMI change (mean of 1.31 and 1.32 kg/m2 per decade in men and women, respectively) in women ({beta} = - 0.14 kg/m{superscript 2}, 95% CI: -0.15 to -0.12; {beta} = -0.02 kg/m{superscript 2}/decade, 95% CI: -0.03 to -0.01, respectively) than in men ({beta} = -0.07, 95% CI: -0.08 to -0.06; {beta} = -0.01, 95% CI: -0.02 to - 0.001, respectively). The associations between baseline BMI and EA were explained by genetic factors in men (rA = -0.10) and by both genetic (rA = -0.17) and unique environmental factors (rE = -0.07) in women. For BMI change, the associations with EA were explained solely by genetic factors (rA = -0.04 in men; -0.06 in women). ConclusionIndividuals with higher EA tend to have lower baseline BMI and slower BMI increases across adulthood. The majority of the associations are primarily genetically mediated.

Both genes and the neighborhood are important for life satisfaction; however, there is little research on gene-environment interactions (GxE) that examines how the effect of genetic endowments varies as a function of the environmental context with life satisfaction as the outcome. This study investigated how neighborhood deprivation moderates the effects of genetic predisposition on life satisfaction. Using data from the German Twin Family Panel (TwinLife), we identified 760 dizygotic (DZ) twins and employed twin fixed-effect models to assess the GxE effects on life satisfaction. The findings reveal that the polygenic score (PGS) for subjective well-being is positively associated with life satisfaction. The effect of PGS for subjective well-being on life satisfaction is strongest for individuals living in moderately deprived areas, while it is weaker for those living in highly deprived and less deprived areas. Thus, there are signs of compensation in less deprived areas and, particularly, diathesis-stress/triggering in highly deprived areas.

IntroductionSick children will be at risk of experiencing growth and development disorders and experiencing severe conditions to decreased quality of life. Quality of care through proper management of sick children under five is a priority. However, in the field of pediatric nursing, there are still obstacles to the application of family empowerment in caring for sick children, so it is important to examine a literature review with a philosophical approach the application of family empowerment in caring for sick children, as an effort to optimize the care of sick children under-five. MethodThis study was based on the results of the Literature Review. Articles were obtained from 3 databases, namely Scopus, Science Direct and PubMed. The keywords used in searching the literature in this study were ((parent) OR (mother) AND (parental AND empowerment) OR (engagement) AND (children) OR (sick AND children)). Articles searched from 2018-2022, which were open access and in English, from this literature review search, found 12 articles. ResultBased on a philosophical approach of family empowerment in the care of sick children under-five, family empowerment interventions with the principle of involving families in care, and increasing family knowledge and skills in caring for sick children can be implemented as an effort to optimize care for sick toddlers. ConclusionThe results of this literature review can be used as a basis for nursing interventions that require parental involvement in caring for sick children. Family empowerment programs that are planned and structured can be applied in the care of sick children at home or in the hospital.

A multiple-birth family is one with or expecting more than one child from the same pregnancy. The purpose of this cross-sectional study was to investigate knowledge about multiple-birth families among midwives and public health nurses working in maternity and child health clinics in Finland. The data were collected with a Finnish language questionnaire in spring 2022. Because relevant questionnaires did not exist, we created a new questionnaire based on existing knowledge and practices. The questionnaire assessed xx themes of multiple-birth knowledge relevant for the target population. The response rate was 50% and the number of respondents was 72. A total of 92 items were assessed and these showed high levels of consistency within themes. The respondents had substantial variation in their levels of multiple-birth family knowledge concerning different themes (Kruskal-Wallis test, p < 0.001). Post-hoc pairwise comparisons revealed many significant differences between themes. The two themes of knowledge of speech development of twins and breast feeding having the lowest level of knowledge, while interaction and support expected by the parents having the highest level of knowledge. The respondents had good knowledge of only five themes of multiple-birth family knowledge. Of all the themes, only knowledge about breast feeding was not significantly related to other themes, except for a weak correlation (r = 0.264, p < 0.05) with knowledge about caring for twins and understanding the situation. The age, educational level and work experience of respondents did not significantly affect their scores (all p > 0.1). Although the respondents had knowledge about early interaction, bonding and supporting the growth and development of child, its application is insufficient or lacking because of the special needs of multiple birth families. Further research is required on the effectiveness of training interventions and on nursing in different nursing contexts.

IntroductionDiabetes mellitus is the most widespread chronic non-infectious disease, with an increase in the frequency in childhood that could be the epidemic of the 21st century. This literature aims to study the philosophy of family center care interventions to improve the quality of life of children with diabetes melitus viewed from three philosophical perspectives, namely ontology, epistemology, and axiology. MethodA literature search was performed on five databases, namely SCOPUS, ProQuest, PubMed, ScienceDirect, SAGEPub, and Google Scholar. Population limitations and diagnoses in this literature of children with diabetes melitus. This research is a quantitative study focusing on publications between 2017-2022. ResultFamily centered care can improve the quality of life of children with diabetes. Children with diabetes successfully manage their disease is possible because parents have understood and received ongoing training and in this case, children with connections to the diabetes care team (family) and medical team play an important role in the management of childrens diabetes. Training and strengthening education helps families to control disease. Teaching children and their families to improve knowledge and control diabetes and metabolic diseases. ConclusionFamily centered care for children with diabetes requires family knowledge about care, training skills, building strong motivation for children with diabetes so that complications do not occur.

Background and AimSocioeconomically disadvantaged people are more likely to have high body mass index (BMI). However whether socioeconomic position moderates genetic susceptibility to high BMI, and whether this effect differs by sex, remains unclear. We aimed to investigate whether educational attainment (EA) moderates the association between genetic liability for high BMI and BMI trajectories across adulthood in females and males. MethodsWe analyzed data from 69,314 participants in the Trondelag Health Study (HUNT), a population-based cohort with genotyping and repeated BMI measures. A polygenic index for BMI (BMI PGI) was calculated, and participants were categorized by EA level. Using linear mixed-effects models stratified by sex, we tested the interaction between BMI PGI, EA, and age on BMI trajectories. ResultsThe relationship between BMI PGI and BMI was non-linear, showing a steeper slope in the upper deciles, and was modified by sex (p<0.001). Sex-stratified analysis showed that EA moderated the effect of BMI PGI on BMI in females (p=0.003) but not in males (p=0.089). Among highly educated females, the BMI difference between the top and bottom BMI PGI deciles was-0.99 kg/m{superscript 2} [95%CI: -1.67 to -0.30] smaller than among those with low education. In males, the corresponding difference was -0.16 kg/m{superscript 2} [-0.71 to 0.39]. Genetic influences on BMI trajectories showed consistent age-dependent patterns across all educational groups, though trajectories differed by sex. Females experienced a steady increase in BMI until age 60, after which it declined. Males had an early rapid increase, then stabilization, followed by a slight late-life decline. ConclusionHigher EA consistently moderates the effect of genetic liability for high BMI in females throughout adulthood, but this protective effect is absent in males. This sex difference suggests that gender-related socioeconomic factors may modulate the expression of BMI-related genetic variants, warranting further investigation into the underlying mechanisms.

BackgroundSince nursing job is perceived as personally and professionally demanding, internal resources such as resilience and coping skills are essential to improve nurses health and wellbeing and therefore work productivity and quality of patient care. ObjectiveTo assess the effect of social support on nurses resilience. Moreover, we investigated the impact of demographic characteristics of nurses on their resilience. MethodsWe conducted an on-line cross-sectional study in Greece. Data were collected during October 2022. We used the Multidimensional Scale of Perceived Social Support to measure social support, and the Brief Resilience Scale to measure resilience. We measured the following demographic characteristics of nurses: gender, age, self-perceived health status, COVID-19 diagnosis, MSc/PhD diploma, and clinical experience. ResultsStudy population included 963 nurses with a mean age of 37.9 years. Nurses experienced moderate levels of resilience and high levels of social support. Multivariable linear regression analysis identified that increased significant others support and increased friends support were associated with increased resilience. Moreover, we found a positive relationship between age and resilience. Also, nurses with good/very good health had higher levels of resilience compared to nurses with very poor/poor/moderate health. Finally, resilience was higher among nurses with MSc/PhD diploma. ConclusionsWe found a positive relationship between social support and resilience among nurses. Understanding of factors that influence nurses resilience can add invaluable knowledge to develop and establish tailored programs. Peer support is essential to improve nurses resilience and promote patient healthcare.

BackgroundPolygenic risk scores (PRSs) have recently become popular in predicting genetic susceptibility to common complex diseases. However, as PRSs only capture part of the genetic risk, imperfect prediction of outcomes is expected. Family history may capture additional genetic effects as well as those of shared family environment. Within-family design have the advantage to control potential bias, such as gene-environmental correlation, assortative mating, and population stratification. Our aims are to investigate the relative influence of PRS and family history on general and abdominal obesity using between and within family approaches. MethodsWe included 50,747 participants of the Lifelines Cohort Study. Body mass index (BMI) and waist-hip-ratio (WHR) were calculated by measured height, weight, waist circumference (WC) and hip circumference. Family history was defined as the number of obese first-degree relatives. PRSs were calculated based on recent large genome-wide association studies for BMI, WC and WHR. The between-family PRS was defined as the mean sibling PRS, and the within-family PRS as the difference between the individual and mean PRS. Linear mixed regression models were used to estimate the effect of (between- and within-family) PRS and family history on BMI, WC and WHR. Structural equation modeling was used to estimate the relative effects of parental PRS (via offsprings PRS) and parental phenotype on offsprings phenotype. ResultsPRS and family history together explained 11.81%, 7.26% and 3.62% of the variance in BMI, WC and WHR, respectively, where family history explained additional variance on top of PRS. Among 2,003 parent-offspring trios, transmission of the PRSs from parents to offspring ({beta}=0.48-0.52) resulted in a significant effect of offsprings PRSs on offsprings BMI, WC and WHR ({beta}=0.14-0.16). In addition, parental BMI, WC and WHR, were strongly positively associated with offsprings BMI, WC and WHR ({beta}=0.14-0.27), independent of the parent-offspring transmission. Between- and within-family PRS had similar effect sizes, while between-family PRS explained more variance than within-family PRS for obesity indices among siblings (1.91% vs 6.70% for BMI, 1.25% vs 4.10% for WC, and 0.72% vs 2.61% for WHR). ConclusionsThe combination of PRS and family history improved the prediction of indices for general and abdominal obesity. In addition to the genetic effects captured by the parent-offspring PRS transmission, parental BMI, WC and WHR also independently influenced offsprings BMI, WC and WHR, reflecting additional genetic effects not captured by PRS as well as effects of the shared family environment. Similar effects of between- and within-family PRSs indicated little bias (e.g., gene-environmental correlations, assortative mating, and population stratification) in the genetic effects on indices of obesity.

Impact- This study provides up-to-date, longitudinal evidence on how mental health shapes subsequent weight development during the critical and rapid growth period of adolescence. - Both adverse and protective dimensions of mental health play a role in shaping adolescent weight development, with evidence that some youths experiencing mental health difficulties exhibited smaller increases in BMI z-score, even when starting from a higher baseline weight status. -It should be acknowledged that in contemporary society, adolescents with emerging mental health difficulties may not necessarily present immediate excessive weight gain but instead follow stable or even declining weight trajectories. Although obesity and mental health problems represent two of the most pressing public health challenges, their developmental interplay remains insufficiently understood. Thus, we examined how depressive and anxiety symptoms, self-esteem, and psychological resilience are associated with weight development during adolescence. We included 1280 11-year-old children from the Finnish Health in Teens cohort, following 814 of them for 4.3 years. Mental health was assessed with validated self-administrated scales at age 11. Psychological resilience was determined by psychological health after exposure to stressful life events. Body mass index z-score (BMIz) and waist-to-height ratio (WtHr) were calculated at ages 11 and 16. Depressive and anxiety symptoms were associated with higher baseline BMIz but smaller increases in mean BMIz during follow-up (p = 0.009, p = 0.005, respectively). High self-esteem was associated with lower baseline BMIz, yet with steeper increases over follow-up (p = 0.002). Resilient adolescents showed lower baseline BMIz compared with non-resilient adolescents but exhibited greater increases during follow-up (p = 0.005). Similar trends were observed for WtHr. These findings highlight that mental health is associated with physical growth in adolescence, emphasising the need to consider mental health when seeking to understand and address patterns of weight development and their underlying dynamics.

IntroductionDespite the evidence that fatherhood has a long-term positive and protective effect on mens health, there is also evidence that fatherhood in the perinatal period can be complex and demanding. The challenging nature of fatherhood during the perinatal period can be further compounded by the experience of preterm birth. Preterm birth, defined as a birth occurring before 37 weeks of gestation, has been identified as a risk factor for maternal stress, anxiety, depression and post-traumatic stress. It can be hypothesised that preterm birth is also a risk factor for fathers mental health; however, as no attempt has been made to systematically review studies that have examined preterm births and fathers mental health during the perinatal period it is currently not known how common or signficant the impact of a preterm birth is on fathers mental health during this life stage. AimThe aim of the systematic review will be to critically appraise the empirical evidence that examined preterm birth and fathers mental health during the perinatal period. DesignSystematic review MethodsThe review will be guided by the PRISMA reporting process. Electronic databases Medline, CINAHL, the Cochrane Library, PsycARTICLES, PsycINFO, Psychology and Behavioural Sciences Collections will be searched to identify studies that meet the inclusion criteria. Studies that researched preterm birth during the perinatal period will be included if fathers mental health was the principal focus of the research, if fathers mental health was in the title and/or aim of the study or if fathers mental health was an outcome or dependent variable. Data will be extracted and presented in narrative form including tables and figures. Trial registrationTrial registration: the protocol for this systematic review has been registered in PROSPERO [CRD42024536317]. https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=536317

BackgroundMental health issue during childhood and adolescence could have a lifelong influence on the quality of life, but its early-life risk factors are unclear. This study aims to explore the association of early childhood body mass index (BMI) on childhood and adolescent mental health. MethodsWe conducted a bi-directional two-sample Mendelian randomization (MR) study to investigate the association between infant and early childhood BMI and childhood and adolescence mental health disorders. Genetic instruments for BMI of 12 childhood age groups (from birth to 8 years old) were extracted from genome-wide association studies of up-to 28,681 European participants, and were used to proxy the primary childhood BMI exposures. Overall childhood BMI from an independent cohort was used as the validation exposure. Genetic associations with four childhood mental health disorders, including behavioural, emotional and social functioning disorders, aggression, and internalizing problems, were obtained from FinnGen and EAGLE consortia. The inverse-variance weighted or Wald ratio method was used as the discovery method, where MR-RAPS, dIVW, MR_cML were used as validation methods. ResultsIn the primary analysis, tthe 1-year-old and 2-year-old BMI were robustly associated with behavioural and emotional disorders onset during childhood and adolescence (OR=1.10, 95%CI=1.01 to 1.19, P=0.024; OR=1.12, 95%CI=1.002 to 1.24, P=0.046; respectively). These findings were replicated for emotional and social functioning disorders onset during childhood. BMI at 2 years old was robustly associated with aggression during childhood (OR=1.02, 95%CI=1.002 to 1.04, P=0.029). The analysis using independent childhood BMI data validated results for aggression. The bi-directional MR showed that none of the childhood mental health disorders had a reverse association with childhood BMI at any timepoint. ConclusionsThis study shows that BMI between 1-2 years old, and between 1.5-2 years old were robustly associated with behavioural and emotional disorder, and aggression, respectively. More attention is needed for early childhood weight control to prevent mental health disorders during childhood.

BackgroundDepression is a major public health concern with a complex etiology, which may also be influenced by the living environment. The first-person visibility represents the most direct way of influence from the physical environment. ObjectivesWe aim to investigate the effect of the visibility of the environment at the residence on self-reported depression among early midlife adults, as well as underlying gene-environment interplay. MethodsThe study used 1867 participants who completed the early midlife follow-u p (mean age: 37.2 years) of the FinnTwin12 cohort. The visibility of the environment at the residence was segmented into three visibility factors: sky, tree, and building. Linear regression was fitted between visibility factors and self-reported depression. Molecular methods using polygenetic risk score and twin design (univariate modeling and bivariate moderation modeling) were applied to explore the gene-environment correlation and interaction. FindingsIn males, a higher proportion of building visibility factor was associated with more depression (beta: 0.20, 95% CI: 0.03, 0.36). Univariate twin models estimated that additive genetic factors accounted for 46%, 29%, and 49% of the variance in sky, tree, and building visibility factors, respectively. Bivariate moderation analyses revealed strong gene-environment interactions between all three visibility factors and self-reported depression in females, while in males, interaction was observed by the building visibility factor. ConclusionUrban design should consider building density and other related characteristics to promote mental well-being. The complex gene-environment interplay informs the need for tailored interventions that account for genetic susceptibility and processes by which persons select their inhabitats.

Health as an inseparable part of human beings needs to be maintained to achieve a complete human health degree. The role of health literacy in attaining optimum health is significant. When associated with nursing, health literacy must be interpreted as a part of the role and function of nursing. However, to understand health literacy, it is necessary to study it from the aspect of scientific formation itself and a nursing perspective. This review proposes an alternative conceptualization of health literacy from a nursing perspective. This review used an integrative search through four databases: ScienceDirect, ProQuest, SAGE Journal, and Google Scholar. Search using various combinations of keywords with the help of Boolean operators, including: health literacy, nursing perspective, nursing, and conceptualization combined as MESH terms. The inclusion criteria are peer-reviewed articles in English that discuss health literacy and nursing perspective. Articles published within the last six years (2017-2022). Research such as literature reviews, dissertations, editorials, commentaries, and other expert opinions are excluded. Ten articles were considered in this literature review. We describe the conceptualization of health literacy from the nurses point of view, the predictors that influence it, the dimensions surrounding health literacy, the implication of health literacy, and how nurses will participate in supporting this health literacy. In the end, this conceptualization will be used as an illustration material to integrate the concept of health literacy into various problems that become nursing tasks.

Childhood socioeconomic position (SEP) can have lifelong effects on health. Many studies have used adult height as a surrogate marker for early-life conditions. In this study, we derived the non-genetic component of height, calculated as the residual from sex-specific standardized height regressed on genetically predicted height, as a surrogate for childhood SEP, using data from the Hispanic Community Healthy Study/Study of Latinos (2008-2011). A positive residual would indicate favorable early-life conditions promoting growth, while a negative residual indicates early-life adversity that may stunt the development. The height residual was associated with early-life variables such as parental education, year of birth, US nativity and age at first migration to the US (50 states/DC), supporting the validity of height residual as a surrogate for early-life conditions. Furthermore, a height residual was positively associated with better cardiovascular health (CVH) and cognitive function among middle-aged and older adults. Interestingly, among <35 years old, the height residual was negatively associated with the "Lifes Essential 8" clinical CVH scores. These results suggest the non-genetic component of height as a surrogate for childhood environment, with predictive value for CVH and cognitive function.

BackgroundNursing interns are at high risk of psychological distress due to academic and clinical stressors. While poor sleep quality is linked to anxiety and depression, the buffering role of social support remains underexplored in this population. AimsTo explore the role of social support in regulating the relationship between sleep and mental health among nursing interns. MethodsA total of 396 nursing interns completed self-administered questionnaires including the Pittsburgh Sleep Quality Index (PSQI), Social Support Rate Scale (SSRS), Generalized Anxiety Disorder-7 (GAD-7), and Patient Health Questionnaire-9 (PHQ-9). Hierarchical regression and simple slope analyses were used to test moderation effects. ResultsPoor sleep quality was significantly associated with higher anxiety ({beta}=0.449, P<0.001) and depression ({beta}=0.535, P<0.001). Social support significantly moderated these relationships. Under low social support, the effects of sleep quality on anxiety ({beta} = 0.602) and depression ({beta} = 0.779) were stronger than under high support (anxiety: {beta} = 0.396; depression: {beta} = 0.515). ConclusionsSocial support buffers the adverse psychological effects of poor sleep among nursing interns. Interventions should integrate sleep hygiene education with strategies to enhance social support.

IntroductionThe purpose of this study is to examine the philosophy of social support from the perspective of the resilience. MethodsThis study used a literature review using the PICOS framework. There are 11 articles in it, articleswere searched from 4 databases namely Sciencedirect, Scopus, PubMed, CINAHL. The keywords used in the literature search were resilience AND social support, AND nurses AND hospital. The search was limited to 2019-2024 publications, full articles, not review articles. The strategy used to search for articlesusing the PICOS framework. Then selected using the PRISMA diagram andobtained eleven articles. Quality assessment of eleven articles using the JBI CriticalAppraisal tool. ResultsTen articles describing the relationship between social support and resilience. Social Support can be used improve resilience in nurses at hospital. ConclusionSocial support is related to psychological resilience. Building resilience and social support can help reduce nurses vulnerability. Policymakers must develop and implement appropriate strategies to increase nurses social support and resilience to improve the quality of nursing care.